Neurosurgeons’ perspective on surgical treatment of glioblastoma: Practices, Beliefs and Willingness to Randomize in surgical trials
Clicks: 1
ID: 318933
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #37 of 104 articles by views in Neuro-Oncology Advances
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background The optimal extent of resection for glioblastoma remains debated, with high-level evidence from randomized controlled trials (RCTs) notably scarce. We aimed to evaluate international surgical practices, perceived quality of evidence, and feasibility of future RCTs through an international survey of neurosurgeons. Materials and Methods An international survey was distributed via EORTC, EANS, CNS, and national societies. We used descriptive statistics to summarize surgical practices and univariate analysis and multivariate regression to identify demographic or institutional factors associated with clinical decision-making. Results Responses were received from 328 neurosurgeons across 38 countries. Participation was predominantly from Europe (81.1%), with 12.2% from North America. Most participants (82.9%) practiced in academic centers. While 60.4% identified supramarginal resection (SMR) as the optimal surgical goal, 37.8% aim for complete resection of enhancing tumor (CRET). 90.2% viewed the evidence for CRET as strong, compared to 63.1% for SMR. Despite these views, 72.6% expressed willingness to randomize patients between CRET and SMR, while 49.4% would be willing to randomize between partial resection and biopsy, if CRET is not feasible. Despite differences in individual practice, willingness to participate in RCTs remained consistent across geographic regions. The incomplete overlap between case-based decisions and general willingness to randomize highlights the importance of case-specific nuances. A paradox was observed where perceived weak evidence correlated with lower willingness to randomize(P < .001). Conclusion There is substantial global willingness among neurosurgeons to participate in surgical RCTs for glioblastoma. These findings provide a foundation for designing future international trials to resolve long-standing controversies regarding optimal surgical strategy for glioblastoma.
| Reference Key |
openalex_W7166078891
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Johnny Duerinck, Louise Lescrauwaet, Philipp Karschnia, Rebeca Pérez Alfayate, Michael D. Jenkinson, Eric Suero Molina, Matthias Simon, Jasper Gerritsen, Jorn Van Der Veken, Thiébaud Picart, Emilie Le Rhun, Giuseppe Minniti, Matthias Preusser, Michael Weller, Mandy Melissa Jane Wittens, Asgeir S Jakola, Alireza Mansouri |
| Journal | Neuro-Oncology Advances |
| Year | 2026 |
| DOI |
10.1093/noajnl/vdag166
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.