Impact of Multiplex PCR Blood-Culture Identification Panels on Clinical Outcomes, Antimicrobial Stewardship and Economic Impact in U.S. Hospitals: A Systematic Review and Meta-Analysis

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ID: 318804
2026
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Abstract
Abstract Background We performed a systematic review and meta-analysis synthesizing evidence on multiplex PCR blood culture identification (BCID) panels and their effects on clinical, antimicrobial stewardship, and economic outcomes. Methods We searched PubMed, Scopus, Embase, CINAHL, Web of Science, and the Cochrane Library for studies evaluating time to appropriate therapy, mortality, length of stay (LOS), antimicrobial optimization, and cost in adult inpatients. Results Twenty studies encompassing 4,587 patients with bloodstream infections across U.S. hospitals were included. BCID implementation showed shorter time to appropriate antimicrobial therapy by 17.28 h (95% CI, −24.00 to −10.56) and hospital LOS by 1.25 days (95% CI, −1.79 to −0.71). No statistically significant effect on mortality was observed (OR, 1.04; 95% CI, 0.81–1.34). Economic outcomes were not significantly different. Conclusions BCID panels were associated with shorter time to effective therapy; however, a timely clinical response is necessary.
Reference Key
openalex_W7165931572 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jamil Muqtadir Bhatti, Sameeullah Bhatti, Irshad Batool, Emil Lesho
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag370
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