Immigration and epigenetic age acceleration in the health and retirement study: differences Between Hispanics and Non-Hispanics

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2026
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Abstract
Abstract We assessed associations between immigrant status (foreign-born vs. not), age at migration (0-15, 16-40, 41-64, vs. non-immigrants), and time since immigration (0-39, ≥40 years, vs. non-immigrants) with epigenetic age acceleration (AA) by Hispanic ethnicity in the Health and Retirement Study (n = 3918). Epigenetic AA was defined as the standardized residual from the regression of epigenetic methylation scores from the Levine/PhenoAge, DunedinPoAm38, and GrimAge clocks on chronological age. Predicted mean AA scores from multivariable linear regression models were used to calculate immigration exposure contrasts (relative to non-immigrants) separately for Hispanics & non-Hispanics. Compared to Hispanic non-immigrants, Hispanic immigrants overall (ContrastGrimAge = -0.17, 95% CI: -0.32, -0.02), those who migrated between ages 0-15 (ContrastGrimAge = -0.3, 95% CI: -0.58, -0.02), and those with shorter (ContrastGrimAge -0.15, 95% CI: -0.32, 0.01) & longer times since immigration (ContrastGrimAge = -0.18, 95% CI: -0.36, -0.01) showed slower epigenetic aging. Compared to non-Hispanic non-immigrants, non-Hispanic immigrants who immigrated between ages 41-64 (ContrastLevine = 0.5, 95% CI: 0.14, 0.87; ContrastGrimAge = 0.34, 95% CI: 0.01, 0.67) and had shorter times since immigration (ContrastLevine = 0.25, 95% CI: 0.02, 0.48) showed faster epigenetic aging. Hispanic and non-Hispanic immigrants may experience differences in epigenetic aging compared to their non-immigrant counterparts.
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openalex_W7165916309 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Antonio Bustillo, M. Maria Glymour, Tali Elfassy, Kaylie Moropoulos, Adina Zeki Al Hazzouri, Katrina Kezios
Journal american journal of epidemiology
Year 2026
DOI
10.1093/aje/kwag145
URL
https://doi.org/10.1093/aje/kwag145
Keywords Keywords not found

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