Association Between Proton Pump Inhibitor Use and Short-Term Postoperative Complications Following Abdominoplasty: A Multi-Institutional Cohort Study

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ID: 318488
2026
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Abstract
Abstract Background Abdominoplasty is a common procedure, especially among patients with obesity, a group in which proton pump inhibitor (PPIs) use is highly prevalent. While there are growing concerns regarding PPI-related complications, there is a lack of data on their effects in aesthetic surgery. Objectives This study aims to assess the association between preoperative use of PPIs and the risk of short-term postoperative complications after abdominoplasty. Methods This multicenter cohort study used the TriNetX Global Collaborative Network. Individuals aged 18 years or older who had abdominoplasty were identified and categorized into two groups based on preoperative PPI exposure: patients with a documented prescription prior to surgery, and those without any recorded history of PPIs prescription. To reduce baseline differences between groups, propensity score matching was conducted to achieve balance in demographic and clinical characteristics. Postoperative outcomes focused on complication rates evaluated at 30, 60, and 90 days after surgery. Results After 1:1 PSM, both groups comprised 2,031 patients each. At 30 days following abdominoplasty, patients who received PPIs prior to surgery exhibited significantly higher risks of surgical site infections (RR 2.467; 95% CI [1.358, 4.48]), wound dehiscence (RR 2; 95% CI [1.079, 3.706]), opioid prescription (RR 1.368; 95% CI [1.269,1.475]) and any surgical site complications (RR 2.545; 95% CI [1.806,3.588]) compared to the control group. These risks persisted at 60- and 90-days post surgery. Conclusions Preoperative exposure to PPIs may increase the risk of short-term postoperative complications following abdominoplasty. Additional studies are needed to define clinical guidelines regarding the perioperative management of these medications.
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Authors Yoram Wolf, Jonathan Zontag, Ron Skorochod, Nir Zontag
Journal Aesthetic Surgery Journal Open Forum
Year 2026
DOI
10.1093/asjof/ojag129
URL
https://doi.org/10.1093/asjof/ojag129
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