A dynamic meiotic cohesin complex regulates synaptonemal complex assembly in Drosophila oocytes
Clicks: 1
ID: 318478
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #316 of 320 articles by views in current genetics
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 320 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
There are two meiotic cohesin pathways that regulate synaptonemal complex (SC) assembly in Drosophila melanogaster. We previously proposed that the kleisin C(2)M, which is required for SC assembly, is the only meiosis-specific component of a complex that includes Stromalin (SA1), Nipped-B, SMC1 and SMC3. The C-terminal and N-terminal domains of C(2)M contain several conserved residues known to interact with SMC1 or SMC3 and form a ring structure in budding yeast. Our mutant analysis has shown that these conserved residues are critical for SC formation. These results suggest that C(2)M may require a ring structure to perform meiosis-specific functions such as the formation of SC, and that each domain has unique functions in SC assembly. We also show that SA1 colocalizes with and depends on C(2)M. However, C(2)M is more dynamic than SA1 or SMC1, and may regulate the dynamics and chromosome loading of SMC1 and SA1. Indeed, C(2)M induces SC assembly when ectopically expressed in germline mitotic cells. We propose that C(2)M specifies the meiotic SC assembly functions to the cohesin complex.
| Reference Key |
openalex_W7165630439
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Margaret Howland, Helen Nguyen, Daria Mitri, Justin Mathew, N B Patel, Mercedes R. Gyuricza, Janet K. Jang, Kim S. McKim |
| Journal | current genetics |
| Year | 2026 |
| DOI |
10.1093/genetics/iyag159
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.