Metabolic profiling of liver tissues in mice after instillation of fine particulate matter.

Clicks: 262
ID: 31835
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #448 of 637 articles by views in The Science of the total environment

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 637 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Human exposure to fine particulate matter (PM) in various environment could lead to a number of adverse health effects. Little is known about the toxic mechanism and the further response caused by PM exposure. In this study, a metabolomics approach using gas chromatography-mass spectrometry (GC-MS) was adopted to evaluate the liver toxicity induced by different gradient concentrations of PM. A multivariate statistical analysis had shown, a total of 12 endogenous metabolites including amino acids and organic acids were identified as potential biomarkers of PM and most of them were down-regulated. By analyzing the metabolic pathways using the identified biomarkers, the significantly interfered metabolic pathways when mice were exposed to PM were found as: glycine, serine and threonine metabolism, aminoacyl-tRNA biosynthesis, cysteine and methionine metabolism, alanine, aspartate and glutamate metabolism, methane metabolism, linoleic acid metabolism and valine, and leucine and isoleucine biosynthesis, all of which were closely related to liver metabolism. The findings of this study reveal detailed toxic metabolic effects of PM in liver tissues, provide ways for assessing the health risk of PM at molecular level, and further offer insights on the potential mechanism of its toxicity.
Reference Key
shi2019metabolicthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shi, Chunzhen;Han, Xi;Mao, Xu;Fan, Chong;Jin, Meng;
Journal The Science of the total environment
Year 2019
DOI
S0048-9697(19)33944-0
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.