Multidisciplinary Care for Older People Living with HIV: Optimizing Medication and Enhancing Quality of Life
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ID: 318345
2026
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Abstract
Abstract Background The growing number of older people living with HIV (PLWH) presents challenges in comprehensive care and maintaining health-related quality of life (HRQoL). This study aimed to evaluate the effect of a multidisciplinary intervention focusing on medication optimization and person-centered support on the HRQoL of older PLWH. Methods This prospective study included 3 groups: PLWH ≥50 years (older); PLWH <50 years (younger); and HIV-negative individuals ≥50 years. Older PLWH underwent a comprehensive assessment at baseline and approximately six months later, with interventions provided by clinical pharmacists, infectious disease specialists, and geriatricians. Medication Regimen Complexity Index (MRCI), STOPP/START and TIME criteria, and 36-Item Short Form Health Survey (SF-36) were used. Results A total of 285 participants were included in this study (50% older PLWH, 25% younger PLWH, and 25% HIV-negative individuals). The mental component summary score of SF-36 was significantly higher in older PLWH compared to younger PLWH at baseline (p=0.001). Antiretroviral therapy regimens were simplified in 24.1%, and at least one medication was deprescribed in 48.9% of older PLWH. Older PLWH demonstrated significant reductions in potentially inappropriate prescribing with STOPP/START and TIME criteria (p<0.001) at the second interview, but no significant changes were observed in MRCI scores (p>0.05). Additionally, physical and mental component summary scores of SF-36 increased significantly (p=0.012 and p<0.001, respectively) after intervention. Conclusion Multidisciplinary care was associated over time with reductions in inappropriate prescribing and improvements in HRQoL among older PLWH. These findings underscore the need for integrated, person-centered, age-tailored HIV care models to support healthy ageing.
| Reference Key |
openalex_W7165519792
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| Authors | F Balli, Emre Kara, Zeynep Şahiner, Cafer Balci, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Meltem Halil, Serhat Ünal, Kutay Demirkan |
| Journal | Open forum infectious diseases |
| Year | 2026 |
| DOI |
10.1093/ofid/ofag378
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| URL | |
| Keywords | Keywords not found |
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