Dietary 25-Hydroxyvitamin D Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs.

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ID: 31833
2019
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Abstract
We conducted this experiment to determine if feeding 25-hydroxyvitamin D (25(OH)D) to weaned pigs would alleviate porcine epidemic diarrhea virus (PEDV) infection and immune response. Forty-two weaned pigs were allotted to 1 of 6 dietary 25(OH)D treatments (5.5, 5.5, 43.0, 80.5, 118.0, 155.5 μg 25(OH)D/kg diet) for 26 days. On day 22 of the trial, all the treatments were orally administrated with PEDV except for one of the 5.5 μg 25(OH)D/kg treatments, which was challenged with the same volume of sterile saline and served as control. Another 5.5 μg 25(OH)D/kg group for PEDV challenge was named CON-PEDV. Average daily gain ( < 0.05) was reduced by PEDV infection. PEDV administration also induced severe diarrhea ( < 0.05), reduction of villous height and the ratio of villous height to crypt depth, and increase of crypt depth and serum diamine oxidase activity ( < 0.05). Serum IgM and complement component 4 levels were increased by PEDV challenge. However, 155.5 μg 25(OH)D/kg supplementation alleviated intestinal damage ( < 0.05) compared with CON-PEDV. Furthermore, 155.5 μg 25(OH)D/kg supplementation downregulated the mRNA abundance of inflammatory cytokines and interferon signal pathway-related genes ( < 0.05) compared with CON-PEDV. These results suggested that dietary supplementation of 155.5 μg 25(OH)D/kg could alleviate intestinal damage and protect against PEDV-induced inflammatory status.
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yang2019dietaryanimals Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jiwen Yang, Gang Tian, Daiwen Chen, Ping Zheng, Jie Yu, Xiangbing Mao, Jun He, Yuheng Luo, Junqiu Luo, Zhiqing Huang, Aimin Wu, Bing Yu
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Journal animals
Year 2019
DOI
E627
URL
Keywords
kalman filtering nonlinear state estimation set-membership systematic uncertainty unknown but bounded error

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