Vertical transmission of Nipah virus in an experimentally infected nonhuman primate; a brief report and description of histopathological lesions

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ID: 318058
2026
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Abstract
Abstract Nipah virus (NiV) is a highly pathogenic henipavirus which causes severe, often fatal disease in humans and animals. African green monkeys (AGM) have been used extensively to investigate NiV disease and are the only nonhuman primate (NHP) model that accurately recapitulates human NiV pathogenesis. Here, we describe histopathological lesions in the reproductive tissues of an incidentally pregnant female AGM that succumbed to NiV disease. We employed multiplex immunohistochemistry techniques to profile specific cell populations which identified NiV antigen in both maternal and fetal cells of the placenta, which has not been previously described in NHP models of NiV disease.
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openalex_W7165464044 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Declan D. Pigeaud, Natalie S. Dobias, Antoinette Lona, Christopher C. Broder, Robert W. Cross, Thomas W. Geisbert, Karla A. Fenton
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag321
URL
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