Genetic analysis of sensitivity to temperature fluctuations identifies acclimation stress as a novel type of cellular stress in Caenorhabditis elegans

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ID: 317794
2026
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Abstract
All organisms must quickly acclimate to short-term environmental temperature changes to maintain optimal physiology. Temperature excursions far from the optimum lead to heat- or cold-shock responses, which have been extensively studied. We hypothesized that, even within a physiological range of temperature whose extremes are not stressful by themselves, the need for constant adjustment to frequent temperature fluctuations might be deleterious. We find that frequent fluctuations between physiological temperatures severely impair the short-term survival of C. elegans in a frequency-dependent manner. We show that the fluctuations impact both the soma and the germline, with the mechanisms that lead to short-term death requiring fertility. Using a survival assay with a candidate gene approach, we identified both hypersensitive and resistant mutants. The nature of the corresponding genes suggests that temperature sensing and mitochondrial function are particularly key to survival under temperature acclimation stress. However, the lack of response from reporter genes designed to reveal classic cellular stresses as well as the molecular identities of the hypersensitive, unaffected, and resistant mutants, suggest that acclimation stress represents a novel type of stress with potentially severely deleterious consequences for animals.
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openalex_W7165178655 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Noah Lilienfeldt, Yifan Tai, HD Sun, Brandon Waddell, Wen Yang, Robyn Branicky, Siegfried Hekimi
Journal current genetics
Year 2026
DOI
10.1093/genetics/iyag157
URL
https://doi.org/10.1093/genetics/iyag157
Keywords Keywords not found

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