Kaposi Sarcoma-Associated Immune Reconstitution Inflammatory Syndrome (KS-IRIS) in Advanced HIV: Challenges in Managing Visceral Disease with Pericardial Involvement

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ID: 317771
2026
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Abstract
Abstract Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication following initiation of antiretroviral therapy (ART) in people with HIV. In this case report, we describe the complex clinical presentation of a 27-year-old ART-naïve male with advanced HIV who developed Kaposi sarcoma-associated IRIS (KS-IRIS) with visceral involvement and pericardial effusion shortly after starting ART. We review known risk factors for KS-IRIS, its clinical manifestations including rare cardiac involvement and paradoxical worsening with steroid use, as well as current evidence for chemotherapeutic and antiviral treatment strategies.
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openalex_W7165191469 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Natalie A. Sturd, Nicole L. Kusnik, Katerina Roma, Alexander Hewlett, Sara H Bares, Jennifer M Davis
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag363
URL
https://doi.org/10.1093/ofid/ofag363
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