Treatment of Familial Multiple Lipomatosis: A Systematic Review

Clicks: 3
ID: 317623
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #146 of 176 articles by views in clinical and experimental dermatology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 176 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: Familial multiple lipomatosis (FML) is a rare hereditary condition characterised by multiple subcutaneous lipomas, most commonly affecting the trunk and extremities. Although benign, the cumulative tumour burden can cause cosmetic disfigurement, discomfort, and functional limitation. Treatment options include conventional excision, liposuction, and injection lipolysis, but no consensus guidelines exist, and evidence remains fragmented. OBJECTIVES: To summarise reported management strategies, outcomes and recurrence rates to better inform clinical decision-making for the management of FML. METHODS: A systematic review was conducted in accordance with PRISMA guidelines using OVID Medline (1946-April 2025) and Embase (1974-April 2025). Of 4259 studies identified, 15 case reports met the inclusion criteria. Data were extracted on demographics, lesion distribution, management, and recurrence. RESULTS: Patients ranged from 14 to 71 years, with a male predominance and strong familial clustering. Lesions were typically soft, mobile, and non-tender, most often located on the arms, thighs, and the trunk. Excision was the primary treatment in most reports (n = 12), followed by liposuction (n = 2) and injection lipolysis (n = 1). Recurrence occurred with both excision and injection therapy, although follow-up data were inconsistently reported. CONCLUSIONS: Minimally invasive excision and liposuction-based approaches show promise for improved cosmesis. However, their interpretation in the current literature remains limited by low level evidence case reports, large heterogeneity between studies and the lack of standardised outcomes. This review consolidates the existing literature on FML, underscoring the need for further studies with patient-reported outcome measures to clarify recurrence risk and optimise management strategies.
Reference Key
openalex_W7165012401 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kieron Young, Dardan Popova, Tonderai Mutsago, Caroline Payne
Journal clinical and experimental dermatology
Year 2026
DOI
10.1093/ced/llag252
URL
https://doi.org/10.1093/ced/llag252
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.