When pain becomes self: limbic-default mode network hyperconnectivity predicts microvascular decompression failure in trigeminal neuralgia
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ID: 317002
2026
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Abstract
Abstract Microvascular decompression is the standard surgical intervention for classical trigeminal neuralgia attributed to neurovascular compression. However, up to 30% of patients experience poor outcomes despite technically successful surgery, suggesting non-peripheral mechanisms. This study investigates whether central neural reorganization—manifested as altered cortico-subcortical connectivity and white matter microstructure—underlies poor surgical outcomes in patients with “incidental” low-pressure vascular contact.
| Reference Key |
openalex_W7164311646
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|---|---|
| Authors | Yue Wang, Chenglong Cao, Hao Chen MM, M T Wu, Xiaosong He, Xiaofeng Jiang MM |
| Journal | Brain communications |
| Year | 2026 |
| DOI |
10.1093/braincomms/fcag220
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| URL | |
| Keywords | Keywords not found |
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