Is Sleep a Mechanistic Factor in the Blood Pressure Lowering Effects of Low-Dose Aspirin Taken at Bedtime? A Pilot Study

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ID: 316954
2026
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Abstract
Abstract Introduction This was a pilot study designed to test the hypothesis that bedtime administration of acetylsalicylic acid (ASA) lowers BP through sleep improvements that impact the inflammatory, and renin-angiotensin-aldosterone system (RAAS). We predicted that ASA would enhance sleep consolidation and lower sympathetic activation, protecting against the physiological stress of fragmented sleep. Materials and methods Seven participants (5F, 2 M, mean age 25.71 ± 4.03 years, BMI 22.40 ± 1.91 kg/m2) completed this within-subject, double-blind, balanced study involving 2x5 in-patient days. Participants were randomized to daily intake of ASA (81 mg/day) or placebo at bedtime for 2 weeks before each hospital research stay that included 1 baseline (BL) night, 2 nights of an experimental sleep disturbance (ESD) protocol and finally, 1 night of recovery sleep. The ESD protocol included 1-hour delayed sleep onset, fragmentation of sleep with 5x20-minute awakenings, and a 1-hour earlier lights on time. Results ASA did not decrease BP following the 2-week at-home ASA administration, nor during ESD. Evening renin was significantly reduced (p = .048), compared to placebo after 2 weeks of ASA. Mood and well-being improved after 2 weeks of ASA. There were statistical trends towards decreased 24-hr average heart rate (p = .053), and increased heart rate variability (HRV) (p = .080). When challenged with the ESD protocol, ASA was associated with a longer duration of individual slow waves (p = .013), lower 24-hr average HR (p < .001) and a trend to greater NREM delta power (p = .061). Conclusions This pilot study is the first investigation exploring effects of ASA on renal & hemodynamic parameters at night, implicating sleep as an important mechanistic factor.
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openalex_W7164320630 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael Vazquez, Huan Yang, Michael R. Goldstein, Monika Haack, Janet Mullington
Journal SLEEP Advances
Year 2026
DOI
10.1093/sleepadvances/zpag058
URL
https://doi.org/10.1093/sleepadvances/zpag058
Keywords Keywords not found

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