Comment on ‘Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma’: can survival associations be inferred from selectively tested populations?
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ID: 316900
2026
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Abstract
In this correspondence, we comment on the recent study by Mistry et al. examining *NRAS* and *KIT* testing patterns and survival in melanoma using a national English cohort. While acknowledging the important contribution of this large real-world dataset, we raise considerations regarding the interpretation of genotype–survival associations derived from selectively tested populations, where clinically driven molecular testing may introduce selection-related biases. We suggest that caution may be warranted when interpreting the apparent lack of prognostic association between *NRAS* mutation status and survival and emphasize the need for more systematically genotyped cohorts to clarify biological prognostic effects.
| Reference Key |
openalex_W7164149117
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|---|---|
| Authors | Xue Xu, Rongying Wang, Qianqian Zhang, Yulin Zou |
| Journal | clinical and experimental dermatology |
| Year | 2026 |
| DOI |
10.1093/ced/llag246
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| URL | |
| Keywords | Keywords not found |
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