Discriminating Bacterial from Nonbacterial Lower Respiratory Tract Infection within Clinical Subgroups of Hospitalized Adults

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ID: 316352
2026
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Abstract
Abstract We previously identified a blood-based 4-gene signature that accurately discriminates bacterial from nonbacterial acute respiratory infection (ARI) in 504 hospitalized adults (AUC = 0.90). Here we evaluate how well this global signature performs within subgroups of patients based on underlying lung disease or presence of pneumonia, comparing it to newly developed subgroup-specific signatures assessing whether performance is improved by tailoring unique gene signatures to homogeneous subgroups. Our global gene signature strongly discriminated bacterial from nonbacterial ARI within every clinical subgroup including pneumonia (AUC = 0.77-0.94), and outperformed every subgroup-specific signature (AUC = 0.57-0.90), suggesting broad applicability in adults with ARI.
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openalex_W7163918001 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ann R Falsey, Derick R. Peterson, Andrea Baran, Edward E Walsh, Soumyaroop Bhattacharya, Angela R Branche, Daniel P. Croft, Thomas J. Mariani
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag297
URL
https://doi.org/10.1093/infdis/jiag297
Keywords Keywords not found

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