Practice effects as a dynamic biomarker of early cognitive change in far-from-onset Huntington’s disease
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ID: 316042
2026
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Abstract
Abstract Although cognitive performance typically appears preserved in far-from-onset Huntingtin Gene Expansion Carriers (HGECs), underlying neuropsychological mechanisms may be subtly altered and remain undetected. Practice effects from repeated task exposure provide a sensitive measure of cognitive adaptability, with early disruptions signaling reduced neural efficiency before standard deficits emerge. This study aimed to examine longitudinal practice effects across annual neuropsychological testing in far-from-onset HGECs and to identify the disease burden threshold where these patterns diverge.
| Reference Key |
openalex_W7163662551
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| Authors | Carla Franch-Marti, Arnau Puig-Davi, Jon Rodríguez-Antigüedad, Jesus Perez-Perez, Gonzalo Olmedo-Saura, Iñigo Ruiz-Barrio, Lidia Bojtos, Laura Perez-Carasol, Adrià Tort‐Merino, Javier Pagonabarraga, J Kulisevsky, Saul Martinez-Horta |
| Journal | Brain communications |
| Year | 2026 |
| DOI |
10.1093/braincomms/fcag210
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| URL | |
| Keywords | Keywords not found |
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