Pharmacokinetics of Oral Amoxicillin for the Treatment of Syphilis in Pregnancy

Clicks: 4
ID: 315913
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #208 of 229 articles by views in Open forum infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 229 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background This open-label study compared single dose oral amoxicillin pharmacokinetics during pregnancy and post-partum relative to the established in vivo minimum inhibitory concentration (MIC) for Treponema pallidum (0.42 mcg/mL). Methods Pregnant women in good health at 24-34 weeks gestational age prescribed amoxicillin for preterm premature rupture of membranes were eligible. A 500 mg oral dose was administered at enrollment and six weeks postpartum. Blood was collected at time 0 (pre-dose) and 1, 2, 3, 4, 6, and 8-hours post-dose; venous cord blood was obtained at delivery. Amoxicillin concentrations were quantified with high-performance liquid chromatography with tandem mass spectrometry. Non-compartmental and population pharmacokinetic analyses were used to summarize parameters and estimate time above MIC (%T>MIC) and time of free drug concentrations >70% MIC (ƒT>70%MIC), for 500, 750, 875 and 1000 mg dosed every 8 or 12 hours. Results Participants (n=13) had a median age of 29 years and gestational age of 31 weeks. Three women (23%) returned for post-partum visits. Amoxicillin concentrations were reduced during pregnancy compared to post-partum: the median 8-hour area-under-the-curve was 14 vs. 22.2 mgxh/L (p=0.007), and oral clearance was 34 vs 22 L/h (p=0.03), respectively. The amoxicillin half-life was 1.3 hours. Simulated 12-hour dosing produced lower %ƒT>MIC results relative to the 8-hour dosing regimens. Conclusions Oral amoxicillin dosed every 8 hours during pregnancy is needed to maintain concentrations above the syphilis MIC threshold. Modeling suggests that 750 mg every 8 hours maintains adequate exposure during pregnancy and should be evaluated in future trials.
Reference Key
openalex_W7163523829 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J Dionne, Akila Subramaniam, Mauricio Kahn, Yumo Xue, Kevin Ryan, Edward P. Acosta
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag336
URL
https://doi.org/10.1093/ofid/ofag336
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.