Amoxicillin Direct Oral Challenge in Hospitalized Patients with High-Risk Allergic Reactions, in a pharmacist directed program

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ID: 315903
2026
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Ranked #103 of 214 articles by views in Open forum infectious diseases

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Abstract
Abstract In 169 hospitalized adults with penicillin allergy histories, either through interview or listed in the electronic medical record of urticaria, angioedema, anaphylaxis, and shortness of breath at least 10 years ago, 94.1% tolerated a direct oral amoxicillin challenge led by a non-allergy specialist and were de-labeled. Mild reactions occurred in 5.9%, with no severe events. This safe, effective approach may improve antibiotic stewardship, reduce costs, and support broader implementation over penicillin skin testing.
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openalex_W7163523195 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bryan Le, Shyam Joshi, Kendall Tucker, YoungYoon Ham
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag344
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