Assessing efficacy of ADCY10 inhibitors in cervical mucus
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ID: 315877
2026
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Abstract
Abstract Male fertility depends on sperm motility, which enables sperm to traverse the female reproductive tract to the site of fertilization. Soluble adenylyl cyclase (sAC) is a key regulator of sperm motility defining it as a promising non-hormonal contraceptive target for women and men. To evaluate the efficacy of sAC inhibitors under conditions mimicking the female reproductive tract, we employed a capillary assay using cervical mucus isolated from humans or cows as well as methylcellulose, a viscoelastic liquid that simulates cervical mucus. Addition of a sAC inhibitor either directly to semen, modeling an on-demand male contraceptive, or to the cervical mucus, approximating a female contraceptive, effectively blocked sperm migration. These studies provide proof-of-concept for the efficacy of sAC inhibitors under physiologically relevant conditions.
| Reference Key |
openalex_W7163591654
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|---|---|
| Authors | Justine Fischoeder, Jai Marathe, Deborah J Anderson, Lonny R. Levin, J Buck, Carla Ritagliati |
| Journal | molecular human reproduction |
| Year | 2026 |
| DOI |
10.1093/molehr/gaag035
|
| URL | |
| Keywords | Keywords not found |
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