ADH1B - ALDH2 genotype combinations, Age-Related Risk, and Field Cancerization in Head and Neck and Upper GI Cancer Screening in 10,073 Alcohol-Dependent Men

Clicks: 19
ID: 315371
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #14 of 49 articles by views in journal of carcinogenesis

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract We analyzed initial endoscopic screening results, including esophageal iodine staining and oropharyngolaryngeal inspection, from 10,073 Japanese alcohol-dependent men (30-79 years) between 1993 and 2025. After adjustment for age, drinking and smoking habits, and screening year, using ADH1B*2 (rs1229984) plus ALDH2*1/*1 as the reference, the cancer risk (OR [95%CI]) associated with slow-metabolizing ADH1B*1/*1 plus ALDH2*1/*1, ADH1B*2 plus inactive ALDH2*2 (rs671), and ADH1B*1/*1 plus ALDH2*2 increased synergistically: 3.06 (2.13–4.39), 10.2 (7.33–14.2), and 21.0 (14.5–30.3) for esophageal squamous cell carcinoma (ESCC; n=309, detection rate 3.1%); 4.34 (2.24–8.41), 11.3 (5.99–21.4), and 27.4 (14.3–52.5) for head and neck squamous cell carcinoma (HNSCC; n=95, 0.9%). ADH1B*2 plus ALDH2*2 increased the OR for gastric adenocarcinoma (GA) to 3.71 (2.19–6.30; n=91, 0.9%). ESCC and HNSCC were already detected at ages 30–39 (ESCC 0.3%, HNSCC 0.6%) and 40-49 (ESCC 1.3%, HNSCC 0.5%), and the corresponding ORs were markedly high in the 30-49 age group: 12.1 (2.62-56.0), 20.5 (4.09-103), and 166 (37.9-730) for ESCC; and 11.8 (1.36-102), 26.4 (2.92-238), and 95.0 (11.5-786) for HNSCC. The age-gradient difference in ORs was significant for ESCC (p = 0.008). ORs by genotype combination did not differ significantly across screening-year periods or by invasive status. Multiple cancers detected in 39.8% of ESCC, 52.6% of HNSCC, and 30.8% of GA. Inactive ALDH2*2 was consistently linked with cancer multiplicity: ESCC OR 2.96 (1.77–4.95), HNSCC OR 14.0 (3.93–49.8), and GA OR 5.41 (1.63–18.0). These results support genotype-informed public health interventions in heavy-drinking East Asian populations.
Reference Key
openalex_W7162874736 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Akira Yokoyama, Tai Omori, Tetsuji Yokoyama
Journal journal of carcinogenesis
Year 2026
DOI
10.1093/carcin/bgag034
URL
https://doi.org/10.1093/carcin/bgag034
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.