Hemolytic anemia due to severe Melody pulmonary valve stenosis caused by histoplasma capsulatum infective endocarditis: a case report

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ID: 315363
2026
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Abstract
Abstract Background Isolated pulmonary valve infective endocarditis (IE) is exceedingly rare, accounting for less than 2% of IE cases. Hemolysis due to right-sided prosthetic valve dysfunction is also poorly described. Case Summary We present a patient with Tetralogy of Fallot and a Melody pulmonary valve replacement who presented with dyspnea on exertion and scleral icterus found to have isolated pulmonary valve IE caused by Histoplasma capsulatum, resulting in severe valve stenosis and intravascular hemolysis. Diagnosis was established through exclusion of other causes of hemolysis, transthoracic echocardiography showing severe prosthetic stenosis, and infectious evaluation identifying Histoplasma capsulatum, confirmed by histopathology of the explanted valve. The patient was treated with antifungal therapy followed by surgical pulmonary valve replacement, leading to clinical improvement. Discussion Fungal endocarditis due to Histoplasma is rare, particularly involving the pulmonary valve. Hemolysis from right-sided valve dysfunction is an extraordinarily rare clinical presentation. This case highlights the importance of considering prosthetic valve IE in unexplained hemolysis and using multimodal diagnostic strategies.
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openalex_W7162861763 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Brock J. Gilsdorf, Charles A. Tharp, Joseph Burke
Journal European Heart Journal - Case Reports
Year 2026
DOI
10.1093/ehjcr/ytag380
URL
https://doi.org/10.1093/ehjcr/ytag380
Keywords Keywords not found

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