A case of penile intraepithelial neoplasia during treatment with Tofacitinib
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ID: 315358
2026
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Abstract
A 41-year-old man with PASH syndrome developed high-grade penile intraepithelial neoplasia five months after initiating tofacitinib for refractory disease. Histopathology confirmed PeIN with diffuse p16 and Ki-67 positivity, and the lesions improved after discontinuation of tofacitinib and treatment with cryotherapy and topical imiquimod. This case highlights a potential association between JAK inhibition and HPV-related neoplasia, underscoring the importance of vigilance for mucocutaneous HPV lesions during treatment.
| Reference Key |
openalex_W7162848466
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|---|---|
| Authors | Pablo Balado‐Simó, Magí Brufau‐Cochs, Natalia Castrejón‐de‐Anta, Irene Fuertes |
| Journal | clinical and experimental dermatology |
| Year | 2026 |
| DOI |
10.1093/ced/llag230
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| URL | |
| Keywords | Keywords not found |
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