Advances in congenital melanocytic naevi

Clicks: 2
ID: 315317
2026
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Ranked #82 of 172 articles by views in clinical and experimental dermatology

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Abstract
Abstract Congenital melanocytic naevi (CMN) are benign melanocytic proliferations originating from neural crest cells, presenting at birth or in early infancy with variable clinical manifestations and malignancy risks. The incidence of CMN varies in different genders, with a higher prevalence in females but with potentially greater complications in males. Genetic studies have highlighted the pivotal role of mutations in BRAF and NRAS in influencing the size and malignancy risk of CMN. Diagnostic challenges necessitate a systematic approach, including histopathology, molecular profiling, and risk-stratified therapeutic selection. This review synthesizes current knowledge on CMN epidemiology, molecular pathogenesis, diagnostic advancements, and therapeutic strategies. Future directions emphasize longitudinal studies to validate interventions, multidisciplinary collaboration, and biomarker-driven personalized management.
Reference Key
openalex_W7162774015 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zeyu Liu, Mingyuan Xu, Jiashe Chen, Wei Tan, Xiaoxiang Xu, Yeqiang Liu
Journal clinical and experimental dermatology
Year 2026
DOI
10.1093/ced/llag219
URL
https://doi.org/10.1093/ced/llag219
Keywords Keywords not found

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