The oomycete effector-targeted nuclear envelope protein StKAKU4 negatively regulates plant immunity via vesicle trafficking

Clicks: 3
ID: 315032
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #407 of 513 articles by views in Plant physiology and biochemistry : PPB

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 513 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Nucleoskeleton proteins modulate nuclear structure and play important roles in diverse cellular processes. Yet, their functions in immune responses are poorly understood. Here, we report that a nucleoskeleton protein, potato lamin-like protein StKAKU4, is targeted and stabilized by the oomycete RxLR effector Pi22798 to suppress immunity. StKAKU4 predominantly localizes to the nuclear envelope (NE) and is frequently trafficked between the NE and endosomal organelles. Enhanced expression of KAKU4 in Nicotiana benthamiana significantly increases Phytophthora infestans infection, whereas silencing of KAKU4 in potato and N. benthamiana enhances resistance, suggesting that it acts as a susceptibility (S) factor. GFP-StKAKU4 accumulates at the extrahaustorial membrane (EHM) during P. infestans infection. Moreover, Pi22798 interacts with StKAKU4 at the NE and accelerates endomembrane trafficking of StKAKU4 to the cytoplasm. An endomembrane enrichment assay indicates that StKAKU4 is involved in intracellular transport. In the immunopurified GFP-StKAKU4-associated endomembrane proteome, both host immunity-associated proteins and several P. infestans RxLR effectors are enriched, whereas apoplastic effectors such as PiSCR74, which do not enter host cells, are not. Our findings reveal a mechanism by which the potato NE protein StKAKU4 is involved in vesicle trafficking and is exploited by P. infestans to facilitate infection and colonization, offering valuable insights into S factors and potential strategies for improving disease resistance.
Reference Key
openalex_W7162393558 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jing Zhou, Jiahui Nie, Yetong Qi, Xinya Wu, Lu Liu, Lei Guo, Xintong Wu, Dong Cheng, Meng Xu, Ruimin Yu, Qingguo Sun, Huishan Qiu, Paul R J Birch, Zhendong Tian
Journal Plant physiology and biochemistry : PPB
Year 2026
DOI
10.1093/plphys/kiag301
URL
https://doi.org/10.1093/plphys/kiag301
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.