Kinetics of enteric pathogen quantity during acute diarrhea in children in resource-limited settings
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ID: 315000
2026
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Abstract
Abstract Pathogen quantity kinetics during childhood diarrhea have implications for etiology ascertainment. Using a multisite cohort, we modeled qPCR quantity by symptom duration. Rotavirus had the largest log reduction in quantity by day 7 (-1.98; 95% CI: -2.88, -1.08), followed by Shigella (-0.87; -1.46, -0.28) and heat stabile toxin-producing E. coli (-0.78; -1.57, 0.02). While peak quantity was robust to host factors, kinetics were not. For example, malnourished children had a minimal decline in Cryptosporidium quantity over the first 7 days of illness. Pathogen quantity, etiology attribution, and non-PCR test sensitivity all peaked early in illness. Diarrheal studies should collect samples early to reduce bias in etiology identification.
| Reference Key |
openalex_W7162436272
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| Authors | William J Lain, Sarah Elwood, Jie Liu, Elizabeth T Rogawski McQuade, Gagandeep Kang, Margaret N Kosek, Aldo ângelo Moreira Lima, Pascal Bessong, Amidou Samie, Rashidul Haque, Estomih Mduma, Jose Paulo Leite, Ladaporn Bodhidatta, Najeeha Talat Iqbal, Nicola Page, Ireen Kiwelu, Zulfiqar A Bhutta, Tahmeed Ahmed, Eric R Houpt, James A Platts-Mills |
| Journal | Open forum infectious diseases |
| Year | 2026 |
| DOI |
10.1093/ofid/ofag309
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| URL | |
| Keywords | Keywords not found |
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