The evolutionary trade-off between immunosurveillance and self-tolerance: Insights from four rheumatologic themes
Clicks: 1
ID: 314724
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #36 of 36 articles by views in modern rheumatology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Host-pathogen interactions have shaped the evolution of the human immune system, sometimes resulting in genetic and acquired trade-offs between robust immunosurveillance and refined self-tolerance. This review examines four representative elements, HLA-B27, tyrosine kinase 2, IL-23 signaling, and anti-citrullinated protein antibodies, to illustrate how these immune components are balanced against the costs of autoimmune disorders. By tracing their evolutionary trajectories, molecular functions, and clinical implications, we aim to elucidate the double-edged nature of immune defense mechanisms and highlight therapeutic opportunities.
| Reference Key |
openalex_W7162112682
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Masaru Kato, Masatoshi Kawataka, Satoshi Yamaguchi, Reina Tsuda, Yoshitomo Morinaga, Tatsuhiko Ozawa, Shiho Fujisaka |
| Journal | modern rheumatology |
| Year | 2026 |
| DOI |
10.1093/mr/roag047
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.