In Vitro Cytogenotoxicity of Novel Tetrazole-Based Schiff Bases and Their Platinum (II) Complexes: A Detailed Analysis Using Chromosomal Aberration, Micronucleus, and Comet Assays

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ID: 314055
2026
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Abstract
Previously, Tetrazole-based Schiff base ligands (TBSL) and their Pt(II) complexes were synthesized and evaluated for cytotoxic activity. The results revealed that low cytotoxicity for the ligands and moderate effects for the Pt(II) complexes compared to cisplatin. Given these promising findings, the genotoxic potential of the Pt(II) complexes was further investigated. Genotoxicity was assessed using in vitro chromosomal aberration, micronucleus, and comet assays. The TBSL exhibited low genotoxicity, whereas the Pt(II) complexes induced higher genotoxic effects; however, these effects were lower than those observed for cisplatin. The low cytotoxic and genotoxic profiles of TBSL support their consideration for further pharmaceutical evaluation. In addition, the genotoxicity findings suggest that the Pt(II) complexes merit further investigation in the context of antitumor drug development.
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Authors Fatma Okuş, Deniz Yüzbaşıoğlu, Gonca Çakmak, Hasan Berk Demirel, Rumeysa Çetin Türker, Fatma Ünal
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Journal mutation research/genetic toxicology and environmental mutagenesis
Year 2026
DOI
10.1093/mutage/geag019
URL
https://doi.org/10.1093/mutage/geag019
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