Frequency and persistence of post-acute symptoms after chikungunya, dengue, Zika, and malaria in travellers: a prospective multi-centre study
Clicks: 3
ID: 314025
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
0.6
/100
3 views
2 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #31 of 52 articles by views in international journal of travel medicine and global health
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background Long term follow-up data on the travel-associated burden of vector-borne diseases (VBDs) are scarce. A prospective multi-site observational study was conducted to delineate the longitudinal course, symptom patterns, physical and mental burden, and factors associated with prolonged illness in travellers after four VBDs. Methods Patients with confirmed travel-associated acute chikungunya, dengue, Zika, or falciparum malaria were recruited at 15 GeoSentinel sites from 2016 to 2021. Persistent signs and symptoms were evaluated at one, three, six, 12 and 18 months (M) post-diagnosis, using a multi-modular study questionnaire with quality of life (QOL) evaluated by 12-item short-form health survey (SF-12). Demographic, premorbid, and acute disease characteristics were tested in multivariate analyses to determine factors associated with persistence of symptoms at M3. Missing data were imputed by rules and statistical methods. Results Among 273 patients enrolled, 35 (13%) had chikungunya, 110 (40%) dengue, 19 (7%) Zika, and 109 (40%) falciparum malaria. Median age was 38 years (interquartile range 30-49), 148/273 (54%) were men. At M3, 24/35 (69%) of chikungunya, 27/110 (25%) of dengue, 8/19 (42%) of Zika, and 12/109 (11%) of malaria patients had persistent symptoms. The proportion of symptomatic chikungunya patients was 18/35 (51%) at M6, mainly due to musculoskeletal symptoms including arthritis and stiffness. In dengue patients, fatigue and musculoskeletal symptoms without arthritis persisted until one year. Zika patients reported persisting headaches, musculoskeletal symptoms including arthritis, and fatigue. One month after malaria, fatigue was the main persisting symptom, which resolved almost completely at M3. At M12, 6/35 (17%) of chikungunya, 5/110 (5%) dengue, 3/19 (16%) Zika, and only 1/109 (1%) of malaria patients were still symptomatic. Impaired QOL was noted at M3 by 23/35 (66%) of patients with chikungunya, 20/110 (18%) with dengue, 6/19 (32%) with Zika, but only 4/109 (4%) with malaria. Female sex, Zika, chikungunya, and musculoskeletal symptoms during acute infection were associated with persistent M3 symptoms. Conclusions Post-arboviral symptoms and impaired QOL persisted beyond six months after chikungunya, dengue and Zika. In contrast, post-malaria fatigue syndrome resolved within three months.
| Reference Key |
openalex_W7161602538
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Davidson H Hamer, Jean Marie Loreau, Ralph Huits, Marta Díaz-Menéndez, Martin P Grobusch, Sapha Barkati, Cédric P Yansouni, F GOBBI, Emmanuel Bottieau, Lin H Chen, Alexandre Duvignaud, Denis Malvy, Francesco Castelli, Silvia Odolini, Cornelis A. De Pijper, Hilmir Ásgeirsson, Lucia Moro, Kei Yamamoto, Adrián Sánchez-Montalvá, Cosmina Zeana, Paul Kelly, Watcharapong Piyaphanee, Daniel Bourque, Anne McCarthy, Fabrice Simon, Philippe Gautret, Jean Baptiste Mardon, G. Texier, Émilie Javelle |
| Journal | international journal of travel medicine and global health |
| Year | 2026 |
| DOI |
10.1093/jtm/taag037
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.