“Approach to the patient with acquired hypothalamic syndrome”

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ID: 313853
2026
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Abstract
The hypothalamus integrates signals from the body and the environment and coordinates homeostatic responses in multiple physiologic processes including: water balance, stress response, temperature regulation, energy balance, feeding behavior, sleep-wake cycles, and reproduction. Endocrinologists care for individuals for whom hypothalamic injury, whether from tumors, their treatment, or other causes, impairs pituitary hormone production and secretion. The extent of other symptoms in affected individuals is also influenced the extent of hypothalamic injury. "Acquired hypothalamic syndrome" refers to this broader collection of problems attributable to hypothalamic injury, variably including not only pituitary hormone deficiencies, but also hypothalamic obesity (or rarely, diencephalic syndrome), sleep and circadian disruption, temperature dysregulation, and behavioral issues (including memory problems and impulse control). Our goal is to present a pragmatic guide to the multidisciplinary, collaborative evaluation and management of hypothalamic syndrome.
Reference Key
openalex_W7160837313 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ellen K. Grishman, Shana E. McCormack
Journal the journal of clinical endocrinology & metabolism
Year 2026
DOI
10.1210/clinem/dgag197
URL
Keywords Keywords not found

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