Machine learning empowers precise discovery of disease-resistance genes in plants

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ID: 313806
2026
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Ranked #132 of 653 articles by views in Plant physiology and biochemistry : PPB

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Abstract
Identifying plant disease-resistance genes is essential for understanding the plant immune system and accelerating the breeding of disease-resistant crops. There is a pressing need for a method capable of accurately identifying plant disease-resistance genes on a genome-wide scale. In this study, we propose Evolutionary Scale Modeling for LRR (ESM-LRR), a deep protein language model designed to accurately predict LRR domains which are substantially variable structures in disease-resistance proteins. ESM-LRR achieved its highest F1 score of 0.80 on a test set using 90% identity as the matching threshold. Building upon ESM-LRR, we developed R-Predictor, a plant disease-resistance gene predictor to simultaneously annotate 15 diverse domain topologies, covering characterized resistance genes across the whole genome. R-Predictor integrates four modules, each employing superior methods that outperform existing methods (achieving F1 scores of 0.89 for RLKs and 0.88 for NLRs), demonstrating its high accuracy and practicality in annotating plant disease-resistance genes. R-Predictor integrated with gene expression profiles to identify candidate R genes associated with grape gray mold and downy mildew, outperforming existing methods and detecting dozens of candidate R genes. Overall, this study presents a novel approach to advancing our understanding of plant immunity and facilitating crop breeding for disease resistance.
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Authors Zhenya Liu, X Wang, Shuo Cao, Tingyue Lei, Zhuyifu Chen, M Zhang, Zhongqi Liu, J M Li, Jianzhong Lu, Wenqi Ma, Bingxiong Su, Yanmei Peng, Yanshuai Xu, X Xu, Wei Zhang, Cong Tan, Chengjie Chen, Yiwen Wang, Yi Zhou
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Journal Plant physiology and biochemistry : PPB
Year 2026
DOI
10.1093/plphys/kiag276
URL
https://doi.org/10.1093/plphys/kiag276
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