Synthesis of plant-derived 6- O -acylated steryl β-glucosides (βASGs) and their derivatives: evaluation of Mincle-mediated signaling activity

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ID: 313732
2026
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Abstract
Abstract Plant-derived 6-O-acylated steryl β-glucosides (βASGs) were investigated as ligands of the C-type lectin receptor Mincle to elucidate their structure–activity relationships. Evaluation of a synthetic monosaccharide βASG library demonstrated that βASGs generally act as Mincle agonists, whereas the deacylated analogue was inactive, indicating an important role for the fatty acyl moiety. Both acyl and sterol structures strongly governed activity, with cholesterol-containing analogues suggesting a relative enhancement toward human Mincle. A comparison of Mincle-mediated signaling activity between βCAG and its α-anomer, Helicobacter pylori-derived cholesteryl 6-O-acyl-α-glucoside (αCAG), showed that αCAG was more potent, pointing to a potential preference of Mincle for certain bacterial glycolipid structures.
Reference Key
openalex_W7160945687 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors K Yoshida, Takanori Matsumaru, Shingo Mochizuki, Sho Yamasaki, Yukari Fujimoto
Journal bulletin of the chemical society of japan
Year 2026
DOI
10.1093/bulcsj/uoag057
URL
https://doi.org/10.1093/bulcsj/uoag057
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