A Digital Health Program Enhances Walking Capacity and Health Status in Symptomatic Peripheral Artery Disease
Clicks: 1
ID: 313704
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #25 of 55 articles by views in European Heart Journal - Digital Health
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background Intermittent claudication (IC) is the most common manifestation of peripheral artery disease (PAD), an atherosclerotic condition associated with high cardiovascular morbidity and mortality. Management targets cardiovascular risk reduction and limb function, but effective non-invasive treatments for limb symptoms remain limited. Objective To evaluate whether a 12-week multimodal smartphone-based digital health program improves walking capacity and symptoms in patients with IC. Design Prospective, multicentre randomized controlled trial. Methods The IPAD trial compared standard care alone with standard care plus a 12-week digital health intervention focused on lifestyle modification and physical activity, incorporating behavioural change techniques and gamification. The primary observer-blinded endpoint was maximum walking distance (MWD) during a six-minute walk test (6MWT), contextualized against minimal clinically important difference (MCID) thresholds. Secondary endpoints included pain-free 6MWT distance and health-related quality of life (HRQoL). Results Over 21 months, 155 patients were randomized 1:1. Mean (SD) age was 71.8 (7.6) years. Compared with controls, the intervention group showed greater improvement in MWD (+21.44 m; 95% CI 6.00–36.87; p=0.007), exceeding the predefined 12-m MCID at the group level, and in pain-free walking distance (+32.95 m; 95% CI 0.68–65.23; p=0.045). The relative risk of achieving an individual 12-m MCID did not differ between groups (RR 1.27; 95% CI 0.91–1.76; p=0.162). Exploratory analysis using a 20.1-m MCID showed a higher proportion of patients achieving the MCID in the intervention group (RR 1.97; 95% CI 1.16–3.34; p=0.012). HRQoL improved nominally, with a between-group benefit on the EQ-5D visual analogue scale (+6.29 points; 95% CI 1.33–11.20; p=0.013). Conclusion The digital-health program resulted in a clinically meaningful improvement in walking capacity in PAD patients with IC.
| Reference Key |
openalex_W7160953341
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Vishal Amlani, Bartosz Dobies, Carl-Magnus Wahlgren, Manne Andersson, Birgitta Sigvant, Anders Gottsäter, Moncef Zarrouk, Olga Nilsson, Hallur Hallsson, Linda Karlsdóttir, Sæmundur Oddsson, Tryggvi Thorgeirsson, J Nordanstig |
| Journal | European Heart Journal - Digital Health |
| Year | 2026 |
| DOI |
10.1093/ehjdh/ztag072
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.