Improving influenza vaccine uptake in low and lower-middle-income countries: A synthesis of interventions and strategic recommendations

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ID: 313673
2026
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Abstract
Abstract Seasonal influenza continues to impose a significant health and economic burden on low and lower-middle-income countries (LLMICs), where vaccine uptake remains critically low. Despite proven benefits of vaccination, the implementation of successful influenza vaccination strategies in these regions is hindered by a complex interplay of multiple barriers, including limited resources, evidence gaps, infrastructural challenges, and socio-cultural factors. Although lessons from high-income countries offer valuable insights, their direct application in resource-constrained settings without contextual adaptation is often ineffective. Exploring the underlying barriers and developing successful interventions tailored to the unique realities of LLMICs is critical, as influenza poses a threat for the next potential pandemic. Multifaceted strategies incorporating culturally informed and risk-group specific interventions, including healthcare provider engagement for vaccine recommendations, promoting local research, leveraging existing platforms, strengthening surveillance systems, and fostering international and domestic support, can facilitate inclusive evidence-based policymaking.
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openalex_W7161254867 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Saleh Haider, Md Zakiul Hassan
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Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag298
URL
https://doi.org/10.1093/ofid/ofag298
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