Antibody-dependent immune complex signalling and inflammatory cytokine responses in acute febrile illness: a mechanistic study in arboviral and leptospiral infection

Clicks: 1
ID: 313605
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #180 of 208 articles by views in Open forum infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 208 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Arboviral infections are characterised by heterogeneity in inflammatory responses and clinical outcomes. Whilst antibodies are essential for protection, antibody–antigen immune complexes may modulate innate immune signalling through Fc receptor engagement. The extent to which immune complex signalling contributes to coordinated cytokine responses in human arboviral infection remains incompletely defined. Methods We conducted a mechanistic immunology study nested within a prospective cohort of patients with acute arboviral infection in southern India. Using paired ex vivo stimulation assays, we compared cytokine responses following antigen-only and antibody–antigen immune complex stimulation. Fc dependence was interrogated using Fcγ receptor blockade and IgG subclass depletion. Cytokines were quantified using the LEGENDplex Human Inflammation Panel (BioLegend). Principal component analysis was applied to identify coordinated cytokine response patterns, and multivariable regression models were used to assess associations with humoral immune state. Results Among 80 participants, immune complex stimulation was associated with higher concentrations of pro-inflammatory cytokines compared with antigen alone. This difference was attenuated by Fcγ receptor blockade and was influenced by antibody subclass composition. Principal component analysis revealed a coordinated cytokine pattern characterised by positive contributions from IL-6, TNF, IL-1β, and CXCL10, with an inverse contribution from IL-10. In multivariable analysis, individuals with lower neutralisation capacity or altered IgG subclass profiles exhibited higher inflammatory cytokine programme scores (β = +1.80 SD; 95% CI 1.54–2.06; p = 7.18 × 10⁻²²). Conclusions These findings suggest that antibody-dependent immune complex signalling may contribute to inflammatory cytokine responses during acute arboviral and leptospiral infection.
Reference Key
openalex_W7161290763 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peter Asaga Mac, Vijeesh Kadukkatti, Philomena Airiohuodion, Brijil Mathew, Sunday Omilabu
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag300
URL
https://doi.org/10.1093/ofid/ofag300
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.