Factor H–Related Protein 1 Deficiency and Risk of Severe Falciparum Malaria in Ghanaian Children: A Cohort Analysis

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ID: 313506
2026
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Abstract
Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H-Related Protein 1 (FHR-1) competes with FH for binding sites, suggesting a potential role in modulating complement activation during infection. Because one-third of Africans carry a CFHR3/1 deletion, we examined the impact of FHR-1 deficiency on malaria severity. We analyzed plasma from 500 Ghanaian children presenting with different clinical manifestations. One-third of plasma samples lacked detectable FHR-1 protein, but logistic regression analysis revealed no association between FHR-1 deficiency and risk of severe malaria. In contrast, FHR-1 deficiency was overrepresented among children presenting with anemia and multiple syndromes and affected children exhibited markedly lower hemoglobin levels. These findings indicate that FHR-1 deficiency does not affect overall progression of severe falciparum malaria, but correlates with severe malaria anemia.
Reference Key
openalex_W7161294679 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alliyah Uhmon Byrd, Lucy Wahler, Thorsten Thye, Timo Reiß, Anna Bachmann, Gabriele Pradel
Journal journal of leukocyte biology
Year 2026
DOI
10.1093/jleuko/qiag063
URL
https://doi.org/10.1093/jleuko/qiag063
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