Inferring patterns of purifying, positive and balancing selection in the coppery titi monkey ( Plecturocebus cupreus ) utilizing a well-fit evolutionary baseline model
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ID: 313371
2026
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Abstract
Despite the coppery titi monkey (Plecturocebus cupreus) being a model system for the study of neurodevelopment and behavior, the evolutionary forces shaping observed levels and patterns of genetic variation in the species have remained poorly studied. In order to illuminate the pervasive effects of purifying and background selection, we have fit a distribution of fitness effects of newly arising exonic mutations, utilizing patterns of polymorphism and divergence based on a recently published high-quality genome assembly. To further characterize episodically acting selective processes, we additionally performed the first whole-genome scans for recent positive and balancing selection in this species, reducing false-positive rates by incorporating the demographic history of the population into an evolutionary null model. These scans identified a small number of biomedically-relevant genes with strong statistical support for having experienced recent selective sweeps or long-term balancing selection. In addition, we identified four genomic deletions bearing the signatures of balancing selection. Taken together, this study provides the first insights into patterns of persistent and episodic selective processes in this species.
| Reference Key |
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| Authors | Vivak Soni, Cyril J Versoza, John W. Terbot, Gabriella J. Spatola, K L Bales, Susanne P Pfeifer, Jeffrey D Jensen |
| Journal | genome biology and evolution |
| Year | 2026 |
| DOI |
10.1093/gbe/evag122
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| URL | |
| Keywords | Keywords not found |
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