Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

Clicks: 120
ID: 31329
2008
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Ranked #350 of 406 articles by views in European journal of medicinal chemistry

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Abstract
In the course of structure-activity relationship studies, diversely substituted 1-(beta- d-acetylatedglucopyranosyl)isoindigo derivatives were prepared from indolines. New 7'-azaisoindigo analogues were also synthesized by coupling a glycosylated isatine and a 7-azaindolin-2-one derivative. Compounds containing a 7'-azaisoindigo framework have never been described before. To get an insight into the substitution pattern required for the best biological potencies, their antiproliferative activities were evaluated toward a human buccal carcinoma cell line (KB) and two human myeloid leukaemia cell lines (K562, HL60).
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bouchikhi2008synthesiseuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bouchikhi, Fadoua;Anizon, Fabrice;Moreau, Pascale;
Journal European journal of medicinal chemistry
Year 2008
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