Efficient mechanochemical synthesis of regioselective persubstituted cyclodextrins

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ID: 31315
2016
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Abstract
A number of per-6-substituted cyclodextrin derivative syntheses have been effectively carried out in a planetary ball mill under solvent-free conditions. The preparation of Bridion® and important per-6-amino/thiocyclodextrin intermediates without polar aprotic solvents, a source of byproducts and persistent impurities, could be performed. Isolation and purification processes could also be simplified. Considerably lower alkylthiol/halide ratio were necessary to reach the complete reaction in comparison with thiourea or azide reactions. While the presented mechanochemical syntheses were carried out on the millimolar scale, they are easily scalable.
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jicsinszky2016efficientbeilstein Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jicsinszky, Laszlo;Caporaso, Marina;Martina, Katia;Gaudino, Emanuela Calcio;Cravotto, Giancarlo;
Journal Beilstein journal of organic chemistry
Year 2016
DOI
DOI not found
URL
https://doi.org/10.3762/bjoc.12.230
Keywords Keywords not found

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