Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma.

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ID: 31184
2019
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Abstract
This article describes the simultaneous determination of bedaquiline fumarate (TMC-207) and rifabutin in human plasma by stable isotope dilution tandem mass spectrometry. The methodology was developed for an investigation of potential drug-drug interactions of the two anti-tuberculosis drugs when given together to healthy human volunteers. Use of the two drugs in combination to treat disease caused by Mycobacterium tuberculosis is contemplated as the bacterium becomes resistant to many currently available drugs.
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gray2019developmentjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gray, Wesley A;Waldorf, Byron;Rao, Manasa Geeta;Stiles, Brenda L;Griffiss, J McLeod;Salata, Robert A;Blumer, Jeffrey L;
Journal Journal of pharmaceutical and biomedical analysis
Year 2019
DOI
S0731-7085(18)32564-0
URL
Keywords Keywords not found

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