Evidence for immunothrombosis according to some markers of thromboinflammation in women with unexplained recurrent reproductive failures
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ID: 311202
2023
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Abstract
Background: Unexplained recurrent reproductive failures (URRF) is a term that describes three different conditions of infertility namely, unexplained infertility (UI), Unexplained recurrent miscarriage (URM) and unexplained recurrent implantation failures (URIF). It is a global reproductive health problem. The aim of the present study was to compare some systemic markers of thromboinflammation in women with unexplained recurrent reproductive failures to controls.
Methods: This was a case-control study involving 70 subjects (35 cases of URRF and 35 healthy control women). The systemic cellular markers of immunothrombosis involving the Platelet Count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), Neutrophil to Lymphocyte Ratio (NLR) and the Platelet to Lymphocyte Ratio (PLR) were determine using the Sysmex XN-10 Automated Hematology Analyzer, Sysmex Corporations Japan. Data was analyzed using One Way Analysis of Variance in GraphPad Prism version 8.0 (Graphpad Software, San Diego, CA, USA) and presented as mean + SD. Statistical significance was defined as p<0.05.
Result: The MPV, PDW and NLR were significantly increased (p = 0.002, 0.007 and 0.028) respectively in the subjects with Unexplained Recurrent Reproductive Failures compared to the healthy controls.
Conclusion: This finding supports an evidence for immunothrombosis in patients with Unexplained Recurrent Reproductive Failures.
| Reference Key |
2026evidence
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|---|---|
| Authors | Alphonsus Ogbonna Ogbuabor |
| Journal | Yemen Journal of Medicine |
| Year | 2023 |
| DOI |
10.32677/yjm.v2i2.4241
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| URL | |
| Keywords | Keywords not found |
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