Hemolytic uremic syndrome: An updated review

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ID: 311149
2022
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Abstract
Hemolytic uremic syndrome (HUS) is a microangiopathic thrombotic disease, which is classified into atypical, typical, and secondary types. Thrombocytopenia, acute kidney failure, and hemolysis are the main features of HUS regardless of its type. Infection with Shiga toxin-producing Escherichia coli causes typical HUS, and gene mutations trigger atypical HUS, while secondary HUS is associated with bone marrow transplantation, autoimmunity, cancer, and other diseases. New insights into the pathogenesis of HUS have emerged over the past decades, suggesting an important role of the complement system in disease pathogenesis, which has been reinforced by the efficacy of plasma exchange and monoclonal antibodies in its treatment. In this review, we performed an updated review of HUS with a focus on understanding its pathogenesis.
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2026article2 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Elmukhtar Habas, Amnna Rayani, Ala Habas, Kalifa Farfar, Eshrak Habas, Ahmed Elmarghani, Abdel-Naser Elzouki
Journal Yemen Journal of Medicine
Year 2022
DOI
10.32677/yjm.v1i1.3346
URL
https://doi.org/10.32677/yjm.v1i1.3346
Keywords Keywords not found

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