Evaluation of Blood-Based Antibody Rapid Testing for HIV Early Therapy: A Meta-Analysis of the Evidence

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ID: 31075
2018
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Ranked #73 of 111 articles by views in Frontiers in immunology

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Abstract
BackgroundWestern blot (WB) assay is considered the gold standard test for HIV infection confirmation. However, it requires technical expertise and is quite time-consuming. WHO recommends blood-based rapid diagnosis to achieve same-day test and treatment. However, this rapid testing strategy has not been promoted worldwide due to inadequate research evaluating the effectiveness of rapid tests (RTs) as an alternative confirmatory HIV test for WB. This study aims to compare the diagnostic performance of rapid HIV tests compared with WB.MethodsPubMed and Web of Science were searched for publications on rapid HIV tests using blood specimen. A meta-analysis was performed to quantitatively evaluate the diagnostic performance of rapid HIV tests compared with the WB assay in terms of pooled sensitivity, specificity, area under summary receiver operating characteristic (SROC) curve, and diagnostic odds ratio (DOR).ResultsTwenty articles involving 27,343 fresh specimens for rapid HIV tests were included in the meta-analysis. Regarding Capillus HIV-1/HIV-2, the pooled sensitivity, specificity, area under SROC curve, and DOR derived from six studies were 0.999 (95% CI, 0.956–1.000), 0.999 (95% CI, 0.991–1.00), 1.00 (95% CI, 0.99–1.00), and 1.0 × 106 (95% CI, 2.6 × 104–3.9 × 107) compared with the WB assay, respectively. With respect to Determine HIV-1/2, the pooled sensitivity, specificity area under SROC, and DOR derived from eight studies were 1.00 (95% CI, 0.789–1.000), 0.992 (95% CI, 0.985–0.996), 1.00 (95% CI, 0.99–1.00), and 1.8 × 106 (95% CI 406.049–7.8 × 109) compared with the WB assay, respectively. Regarding two-step serial RTs, the pooled sensitivity, specificity area under SROC, and DOR derived from eight studies were 0.998 (95% CI, 0.991–1.000), 0.998 (95% CI, 0.994–0.999), and 1.00 (95% CI 0.99–1.00) compared with the WB assay, respectively.ConclusionOur meta-analysis results may provide evidenced-based support for substituting RT for WB. Blood-based rapid HIV tests have comparable sensitivity and specificity to WB for HIV early therapy.
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Authors Huang, Xiaojie;Liu, Xinchao;Chen, Jieqing;Bao, Yugang;Hou, Jianhua;Lu, Xiaofan;Xia, Wei;Xia, Huan;Song, Aixin;Liu, Zhiying;Su, Bin;Chen, Hui;Chen, Yaokai;Chen, Yaokai;Wu, Hao;
Journal Frontiers in immunology
Year 2018
DOI
DOI not found
URL
https://www.frontiersin.org/article/10.3389/fimmu.2018.01458/full
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