Polyoxazolines based mixed micelles as PEG free formulations for an effective quercetin antioxidant topical delivery.

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ID: 3107
2019
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Abstract
This study aims to prove the value of the polyoxazolines polymer family as surfactant in formulations for topical application and as an alternative to PEG overuse. The amphiphilic polyoxazolines (POx) were demonstrated to have less impact on cell viability of mice fibroblasts (NIH3T3) than their PEG counterparts. Mixed micelles, made of POx and phosphatidylcholine, were manufactured using thin film and high pressure homogenizer process. The mixed micelles were optimized to produce nanosized of vesicles about 20 nm with a spherical shape and stable over 28 days. The natural lipophilic antioxidant, quercetin, was successfully encapsulated (encapsulation efficiency 94±4 % and drug loading 3.6±0.17 %) in the mixed micelles with no morphological variation. Once loaded in the formulation, the quercetin impact on cell viability of NIH3T3 was decreased while its antioxidant activity remained unchanged. This work highlights the capacity of amphiphilic POx to create, in association with phospholipids, stable nanoformulations which show promise for topical delivery of antioxidant and ensuring skin protection against oxidative stress.
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simon2019polyoxazolinesinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Simon, L;Vincent, M;Le Saux, S;Lapinte, V;Marcotte, N;Morille, M;Dorandeu, C;Devoisselle, J M;Bégu, S;
Journal International journal of pharmaceutics
Year 2019
DOI
S0378-5173(19)30560-5
URL
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