Mechanosynthesis, characterization, and anti-microbial screening of Cd (II) and Ni (II), chelates of paracetamol and aspirin

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ID: 309383
2025
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Abstract
This paper reported the Mechanochemical synthesis of Cd(II) and Ni(II) complexes of aspirin and paracetamol by simple grinding of their metal  chlorides in the absence of solvent. The mechanochemical products were characterized by solubility, melting points, conductivity values, magnetic moment and IR analyses. Job's method analyses suggested 1:2 metal to ligand ratio for both paracetamol and aspirin complexes. All the complexes have low molar conductance values (2.470 to 3.885 Ω-1gdm-3) for aspirin complexes and (2.065 to 1.875 Ω-1gdm-3) for paracetamol complexes indicating their non-electrolytic nature in dimethyl sulfoxide (DMSO). The complexes are all soluble in dimethyl famamide (DMF) and DMSO.  Paracetamol complexes are soluble in acetone, methanol, and diethyl ether (DEE). Aspirin is soluble in methanol, DMF and DMSO whereas it complexes are all insoluble in water. The magnetic moment values have proved that all the synthesized complexes are paramagnetic with cadmium complexes being diamagnetic. The complexes decompose at a temperature range of 167.8-193.7 °C higher than those of their ligands revealing their higher thermal stability compared to the ligands 170 °C and 137 °C for paracetamol and aspirin respectively. The ligands and complexes were screened against two bacteria isolates and two fungi isolates; Escherichia coli, Staphylococcus aureus, Mucus specie and Candida specie respectively, for antimicrobial activity. The results show that the ligands are inactive against most of the test organisms. Most of the complexes are active in all test concentration, while paracetamol complexes are only active at high concentration
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Authors R. H. Dogarai
Journal Aminu Kano Academic Scholars Association Multidisciplinary Journal
Year 2025
DOI
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URL
https://akasa.com.ng/ojs/index.php/journal/article/view/141
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