An Innovative Sintering Technique in Pharmaceutical Industry

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ID: 309278
2023
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Ranked #90 of 153 articles by views in International Journal of Pharmaceutical Drug Design (IJPDD)

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Abstract
The pharmaceutical dosage form is the dosage form by which active pharmaceutical ingredients are supplied to the patient as a unite dose, to provide a pharmaceutical effect in the body with minimum undesirable side effects. The most common dosage forms are solid dosage form (tablets, capsules, powders and granules in sachet, etc.) due to their excellent physical and chemical stability, cost effectiveness and are easy of manufacturing. Solid dosage form contains a unit dose of one or more APIs with an inert excipient. The tablets are formulated by traditionally either compression methods (Direct/ Wet/ Dry granulation) or an innovative sintering method after compression. The sintering is expressed as the joining of adjacent particles in a mass of powder, or in tablets, by the heat application. Conventional sintering technique involves heating of compact mass at a temperature below the melting point of the available solid constituents in a controlled environment. The sintering technique has manifold advantages over traditional dry or wet granulation method like minimum quantity of drug polymer ratio, easy tailoring of drug release profile, cost effective, high mechanical strength and less disintegration time for the manufacturing of modified release dosage forms. Sintering concept not only improves mechanical strength of dosage form, but it also controls the release of medicament on over an extended time period.
Reference Key
imported_1761930190_6904ebce40943 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rajesh Agrawal
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2023
DOI
10.62896/70syrx59
URL
https://ijpdd.org/index.php/files/article/view/71
Keywords Keywords not found

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