Exploring Innovative Approaches in Gastro‐retentive Drug Delivery Systems

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ID: 309275
2024
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Ranked #142 of 153 articles by views in International Journal of Pharmaceutical Drug Design (IJPDD)

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Abstract
Gastroretentive drug delivery systems have emerged as a potential solution to enhance the bioavailability and efficacy of various pharmaceutical compounds. This review systematically evaluates the advantages and limitations of gastroretentive systems in drug delivery. The primary objective is to comprehensively analyze their mechanisms, formulationstrategies, and potential applications, focusing on their ability to prolong gastric residence time and improve drug absorption. Advantages of gastroretentive drug delivery systems include their capability to prolong drug release, maintain therapeutic concentrations, and reduce dosing frequency. This extended gastric residence time presents a viable approach for drugs with a narrow absorption window or those targeting specific regions of the gastrointestinal tract. Furthermore, these systems have the potential to improve patient compliance and, in turn, treatment outcomes. However, the review also highlights several challenges associated with gastroretentive systems. Variability in gastric emptying, potential gastrointestinal side effects,risk of local irritation, and complex formulation and manufacturing processes pose significantlimitations. Moreover, regulatory concerns and the potential risk of device dislodgement or aspiration require careful consideration.This review consolidates the current understanding of gastroretentive drug delivery systems, emphasizing the need for further research to address these limitations. Future advancements in formulation techniques, innovative design strategies, and a better comprehension of patient variability are essential to optimize the safety, efficacy,and applicability of these systems in clinical practice.
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imported_1761930172_6904ebbcec2dd Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mohini Rithoriya, Dr. Akash Yadav, Dr. Dinesh Kumar Jain
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2024
DOI
10.62896/w1rxyz81
URL
https://ijpdd.org/index.php/files/article/view/81
Keywords Keywords not found

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