Synthesis and Antimicrobial Evaluation of 1,4 -Naphthoquinone Derivatives as Potential Antibacterial Agents

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ID: 309228
2024
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Ranked #58 of 153 articles by views in International Journal of Pharmaceutical Drug Design (IJPDD)

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Abstract
1,4‐Naphthoquinones are an important class of compounds present in a number of natural products. In this study, a new series of 1,4‐naphthoquinone derivatives were synthesized. All the synthesized compounds were tested for in vitro antimicrobial activity. In this present investigation, two Gram‐positive and five Gram‐negative bacterial strains and one pathogenic yeast strain were used to determine the antibacterial activity. Naphthoquinones tested for its antibacterial potencies, among seven of them displayed better antimicrobial activity against Staphylococcus aureus (S. aureus; 30–70 μg/mL). Some of the tested compounds showed moderate to low antimicrobial activity against Pseudomonas aeruginosa (P.aeruginosa) and Salmonella bongori (S. bongori; 70–150 μg/mL). In addition, most active compounds against S. aureus were evaluated for toxicity to human blood cells using a hemolysis assay. For better understanding, reactive oxygen species (ROS) generation, time‐kill kinetic study, and apoptosis, necrosis responses were investigated for three representative compounds.
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Authors Mohd. Mujahid
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2024
DOI
DOI not found
URL
https://ijpdd.org/index.php/files/article/view/154
Keywords Keywords not found

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