Formulation and Evaluation of an Anti-Acne Herbal Gel Using Ginkgo Biloba, Turmeric Extract, Bergamot Oil, and Vitamin E Oil

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ID: 309157
2025
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Ranked #91 of 153 articles by views in International Journal of Pharmaceutical Drug Design (IJPDD)

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Abstract
This study aimed to develop and evaluate a Carbopol 940-based herbal gel containing extracts of Ginkgo biloba and turmeric (Curcuma longa), combined with bergamot oil and vitamin E oil, for potential anti-acne applications. Ethanolic extracts were prepared from Ginkgo biloba leaves and turmeric rhizomes, followed by phytochemical screening. Three gel formulations were developed with varying concentrations (1%, 2%, and 3% w/w) of the combined herbal extracts, supplemented with fixed amounts of bergamot oil (0.5% w/w) and vitamin E oil (0.5% w/w). The gels were evaluated for physical appearance, antimicrobial activity, skin irritation, pH, spreadability, and viscosity. The formulations were stable, yellowish-orange, and homogeneous, with no skin irritation observed. Spreadability ranged from 32.14-37.5 g.cm/sec, viscosity varied from 17,000-264,000 cP across shear rates, and pH was between 6.8-7.5, aligning with skin physiology. Gel-III (3% w/w herbal extract) exhibited the highest antimicrobial activity against Escherichia coli (zone of inhibition: 16.5 ± 0.5 mm). The 3% w/w formulation demonstrated superior antimicrobial and physicochemical properties, suggesting its potential as an effective anti-acne topical treatment.
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imported_1761926402_6904dd02b3063 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sonali Pawar, Yashraj Khot, Sanjari Rupapara
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2025
DOI
10.62896/ijpdd.2.5.03
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