Formulation and Evaluation of Fast Dissolving Oral Film of Lisinopril

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ID: 309139
2025
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Abstract
The present study focuses on the formulation and evaluation of fast-dissolving oral films of Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor used for the management of hypertension. Fast-dissolving films offer several advantages over conventional oral dosage forms, such as ease of administration, enhanced patient compliance, and rapid drug release. Various formulation strategies were employed, including the use of different polymers and excipients to optimize the film's mechanical properties, disintegration time, drug release profile, and stability. The films were prepared using a solvent-casting method and evaluated for appearance, thickness, weight, folding endurance, tensile strength, disintegration time, moisture content, and assay. Formulation F7 showed the best performance, with a rapid disintegration time of 32 seconds, excellent mechanical properties, and a high cumulative drug release (98.89%) at 10 minutes. The in-vitro drug release profile of F7 followed the Peppas model with a non-Fickian diffusion mechanism. Stability studies indicated minimal changes in drug content over a 3-month period, confirming the stability of the optimized formulation. These findings suggest that F7 could serve as a promising fast-dissolving oral film for the delivery of lisinopril, offering a patient-friendly and efficient alternative to conventional tablets.
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imported_1761926376_6904dce831b28 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Aarti Singh Kushwah*, Sunil Shah, B. K. Dubey, Deepak Kumar Basedia, Prabhat Kumar Jain
Journal International Journal of Pharmaceutical Drug Design (IJPDD)
Year 2025
DOI
10.62896/ijpdd.2.7.02
URL
https://ijpdd.org/index.php/files/article/view/306
Keywords Keywords not found

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